Autologous Chondrocyte Transplantation / Implantation Versus Existing treatments

Chondral defects
Which Hospitals?
Your Participation
Study Documents
Local Coordinators
Rehab Physios


Welcome to the ACTIVE trial web site. ACTIVE is a large multi-centre randomised trial designed to compare the long term effectiveness of a cell grafting technique known as autologous chondrocyte implantation (ACI) with existing surgical treatments for articular cartilage defects in the knee. The surgical treatments in the trial all aim to relieve painful symptoms and help patients return to an active lifestyle. However, there is still great debate as to which is the best treatment for articular cartilage defects in the knee. But one thing is clear - without effective treatment such defects can lead to further destructive joint disease requiring a total knee replacement.

The ACTIVE Trial is no longer recruiting new participants, however we may be running other studies that might interest you. Please contact the trial manager on 01691 404142 or email

Information for participants, including Trial newsletters, can be found under "Participants" on the left of this page.

Information for trial site staff, inlcuding current versions of trial related documents and forms are available in the section under "Professionals" on the left of this page.

The Trial Manager welcomes feedback from users with any relevant information or suggestions.

This web site was launched on 15.04.2005 by Heather Smith

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ACTIVE is being carried out by the Robert Jones & Agnes Hunt Orthopaedic & District Hospital NHS Trust in collaboration with the University of Birmingham Clinical Trials Unit and Health Economics Facility. The trial is funded by the Medical Research Council and administrated by Keele University.